Welcome

Research in the Sutton Lab focuses on, in and around water. Whether the project is how water binds the excipients and active to make a granulation that becomes a tablet, or how a weakly basic active pharmaceutical ingredient (API) precipitates when it is emptied from the stomach into the small intestine, or how food and water affects how the tablet disintegrates and the API dissolves or how the plastic bottle that carries your water is degraded into tiny particles that sop up organic waste in the ocean and potentially finds its way into our food, or the physiologically pharmacokinetic modeling of nanoparticles in the mouse, to predict their fate in humans Рit is all about water.

  • Determine the mechanisms by which persistent organic pollutants (POPs) associated with nano-sized fragments of ocean-sourced plastic find their way into living organisms.

 

  • ¬†Investigate the nuances of weakly basic drugs (WBD) that predispose them to precipitate in the intestine after oral administration. The goals of this research are 1) to predict in silico whether a WBD will precipitate in vivo, and 2) to determine ways to prolong the supersaturation of WBD, thus improving their oral bioavailability.

 

  • ¬†Predict the effects of food on the oral efficacy of drugs.

 

  • Predict the pharmacokinetics of nanoparticles after oral ingestion in humans using physiologic models developed in the mouse.